In 2012 the European Cardiovascular Research Institute (ECRI) was founded as a European collaborative effort to perform Investigator Sponsored Studies in the field of cardiology.
IVUS CHIP UPP Registry
IVUS CHIP UPP Registry is an observational, prospective study that aims to summarize patient and procedural information, as well as clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) with IVUS guidance. Given the scarce clinical trial data on demographic minorities in the United States of America, this registry focuses exclusively in gatherting information patients that self-identify within a census-defined demographic minority. This externally-supported, high-quality clinical registry will generate data that will allow comparisons with contemporaneous IVUS-guidance PCI clinical trials in the US, Europe, and Asia.
The Coordinating Principal Investigator is Dr. David Kandzari (Piedmont Heart Institute, Atlanta, Georgia) joint by two Co-Principal Investigators, Dr. Dawn Abbott (Lifespan Cardiovascular Institute, Providence, Rhode Island) and Dr. Wayne Batchelor (Inova Heart and Vascular Institute, Fairfax, Virginia). Three prominent interventional cardiologists that over the past decade had shown outstanding leadership on generating data in patient populations that were traditionally underrepresented in clinical trials. The Steering Commitee also includes Dr. Joost Daemen (Erasmus Medical Center and Cardialysis, Rotterdam, The Netherlands) who is Director of the Angiographic and IVUS Core Lab at Cardialysis, Prof. Jan Tijssen (European Cardiovascular Research Institute & Cardialysis, Rotterdam, The Netherlands), biostatistician of the trial, and Dr. Ernest Spitzer (European Cardiovascular Research Institute & Cardialysis, Rotterdam, The Netherlands), who is the Sponsor representative.
The European Cardiovascular Research Institute (ECRI) is the Sponsor of the IVUS CHIP UPP Registry, which is fully funded through a research grant from Boston Scientific Corporation (Marlborough, Massachusetts, USA). Without the research grants program at Boston Scientific, this important investigation would not be possible.
The IVUS CHIP UPP Registry is registered at ClinicalTrials.Gov: NCT06625801.
The rationale and study design was published in June 2025, and is available online via: https://pubmed.ncbi.nlm.nih.gov/40562607/
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